Thursday June 3, 2010


Q: How Desmopressin (DDAVP) helps in coagulation?


Answer: Desmopressin (DDAVP) helps in coagulation via 2 mechanism

1. Desmopressin stimulates release of factor VIII and von Willebrand factor (vWF) from endothelial cells due to stimulation of the V1a receptor.

2. Desmopressin is shown to be efficacious even in bleeding disorders not involving a deficiency or dysfunction of factor VIII or vWF, including congenital and acquired defects of platelet function as those associated with chronic kidney and liver diseases.



Reference: Click to get abstract
How do you treat bleeding disorders with desmopressin? - Postgrad Med J 2007;83:159-163