Wednesday June 30, 2010

Q: 52 year old male is admitted with unstable angina and going to 'cath. lab' for probable coronary stenting. Cardiologist called you to replace Plavix (Clopidogrel) from protocol to Effient (prasugrel). What would be the replaced dose?


Answer: Loading dose of 60 mg followed by 10 mg per day

Prasugrel (Effient) is a new platelet inhibitor (like Plavix) developed for use in acute coronary syndromes planned for percutaneous coronary intervention (PCI).
It has been said (or claimed) that compared to clopidogrel, 'prasugrel' inhibits adenosine diphosphate–induced platelet aggregation more rapidly, more consistently, and to a greater extent than do standard and higher doses of clopidogrel.